MI Decision Aid Study

With the expertise of Darin Zahuranec, MD, MSc, and Adam Stein, MD, the Levine Team has conducted two pilot studies from April to September 2023 in preparation for a November 2023 grant submission. Pilot 1 involves testing the feasibility of recruitment and data collection procedures planned for a multi-center trial of decision aids in older…

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EPILEPSY COG Project

We have collaborated with PI Hyunmi Choi, MD, at Columbia University in New York, for the study entitled “Effects of Vascular Risk Factors on Risk for Dementia and Stroke After Late-Onset Epilepsy (EPILEPSY COG).” U-M is a subcontract and Deb Levine is the U-M site PI. At U-M, Emily Briceño is a co-I on the…

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BP COG Project

BP COG Project

The BP COG study is a National Institutes of Health (NIH) / National Institute of Neurological Disorders and Stroke (NINDS)-funded R01 study that aims to determine the effect of high blood pressure over the life course on the risk of cognitive impairment and dementia in Blacks, Hispanics, and Whites, and to estimate the potential impact of optimal high blood pressure treatment intensity to reduce racial/ethnic disparities in cognitive impairment and dementia.

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MCI DeM Project

MCI DeM Project

The MCI DeM study is a National Institutes of Health (NIH) / National Institute on Aging (NIA)-funded R01 study that aims to compare the quality of cardiovascular disease care in adults with and without mild cognitive impairment (MCI) and to determine the influence of MCI on patient preferences and physician recommendations for heart attack and stroke treatment.

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More older adults should be checking blood pressure at home

Only around half of those who have hypertension or conditions linked to blood pressure regularly monitor, but health care providers’ recommendations increase older adults’ monitoring at home. Only 48% of people age 50 to 80 who take blood pressure medications or have a health condition that’s affected by hypertension regularly check their blood pressure at home…

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Journal of Stroke and Cerebrovascular Diseases: Mild cognitive impairment and receipt of procedures for acute ischemic stroke in older adults

Older patients with pre-existing mild cognitive impairment (MCI) receive less evidence-based care after acute myocardial infarction, however, whether they receive less care after acute ischemic stroke (AIS) is unknown. We compared receipt of guideline-concordant procedures after AIS between older adults with pre-existing MCI and normal cognition.

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Lab Notes Brain, Image by Stephanie King

Women Experience Faster Cognitive Decline with Age- Michigan Health News

A new analysis finds higher baseline cognition scores for aging women, but a more rapid drop once cognitive decline begins. JAMA Netw Open. 2021;4(2):e210169. doi:10.1001/jamanetworkopen.2021.0169 Deborah A. Levine, MD, MPH1,2,3; Alden L. Gross, PhD4; Emily M. Briceño, PhD1,3,5; et al Women may start middle age with stronger brain function than men, but as they get older, women’s cognition declines faster. That’s according to…

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JAMA Netrwork

JAMA Network Open: Sex Differences in Cognitive Decline Among US Adults

Does the risk of cognitive decline among US adults vary by sex? Description: Sex differences in dementia risk are unclear, but some studies have found greater risk for women. The objective of our study was to determine associations between sex and cognitive decline in order to better understand sex differences in dementia risk.  In this…

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Lab Notes Brain, Image by Stephanie King

Stroke: Interventions Targeting Racial/Ethnic Disparities in Stroke Prevention and Treatment

The risk and outcomes of cardiovascular disease (CVD), including stroke, are not distributed randomly throughout society. Instead, CVD risk and outcomes disproportionately affect some groups more than others, including certain racial/ethnic minorities. This special report aims to summarize selected interventions to reduce racial/ethnic disparities in stroke prevention and treatment and reviews the social determinants of health and the determinants of racial/ethnic disparities in care.

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U-M REACH OUT

This study will: 1) extend the data collection of Reach Out, our ongoing clinical trial to explore innovative mobile health approaches of measuring cognition and blood pressure among our predominately work-age African American participants; and 2) estimate the prevalence of dementia among hypertensive Emergency Department patients to better understand Emergency Department patients’ needs.

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U-M Sleep SMART

This phase III, open-label, blinded-endpoint assessment, multicenter, randomized, controlled trial will test the effect of treatment of obstructive sleep apnea with CPAP after acute ischemic stroke reduces mortality and cardiovascular events and improves stroke recovery.

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U-M CAPRA

The Center to Accelerate Population Research in Alzheimer’s (CAPRA) is focused on science that informs government and healthcare organization actions to address the negative impacts of dementia on health and financial well being of individuals and the population.

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U-M/USC LASI

This study will determine the relationship of educational attainment, cardiovascular health, and ambient air pollution to the risk for cognitive decline and dementia in a nationally-representative sample of adults in India using new data from the Longitudinal Aging Study in India (LASI).

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U-M HRS HCAP

This study will conduct a follow-up to the 2016 Health and Retirement Study (HRS) Harmonized Cognitive Assessment Protocol (HCAP) sub-study.

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U-M BASIC COG

This project aims to use door-to-door surveillance in Texas, a non-immigrant, bi-ethnic community, to determine the prevalence and trajectory over time of cognitive impairment and dementia in Mexican Americans and non-Hispanic whites.

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U-M BASIC

The Brain Attack Surveillance in Corpus Christi (BASIC) project is a population-based stroke surveillance project of a non-immigrant community of Mexican Americans and non-Hispanic whites in Nueces County, Texas.

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STROKE COG Project

STROKE COG Project

The STROKE COG study is an NIH-funded R01 study that aims to advance the understanding of post-stroke dementia and how post-stroke blood pressure, glucose, and lipid levels independently contribute to post-stroke dementia risk.

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