With the expertise of Darin Zahuranec, MD, MSc, and Adam Stein, MD, the Levine Team has conducted two pilot studies from April to September 2023 in preparation for a November 2023 grant submission. Pilot 1 involves testing the feasibility of recruitment and data collection procedures planned for a multi-center trial of decision aids in older…
We have collaborated with PI Hyunmi Choi, MD, at Columbia University in New York, for the study entitled “Effects of Vascular Risk Factors on Risk for Dementia and Stroke After Late-Onset Epilepsy (EPILEPSY COG).” U-M is a subcontract and Deb Levine is the U-M site PI. At U-M, Emily Briceño is a co-I on the…
The BP COG study is a National Institutes of Health (NIH) / National Institute of Neurological Disorders and Stroke (NINDS)-funded R01 study that aims to determine the effect of high blood pressure over the life course on the risk of cognitive impairment and dementia in Blacks, Hispanics, and Whites, and to estimate the potential impact of optimal high blood pressure treatment intensity to reduce racial/ethnic disparities in cognitive impairment and dementia.
The MCI DeM study is a National Institutes of Health (NIH) / National Institute on Aging (NIA)-funded R01 study that aims to compare the quality of cardiovascular disease care in adults with and without mild cognitive impairment (MCI) and to determine the influence of MCI on patient preferences and physician recommendations for heart attack and stroke treatment.
Only around half of those who have hypertension or conditions linked to blood pressure regularly monitor, but health care providers’ recommendations increase older adults’ monitoring at home. Only 48% of people age 50 to 80 who take blood pressure medications or have a health condition that’s affected by hypertension regularly check their blood pressure at home…
People with high blood pressure levels face a faster erosion of their ability to think, make decisions and remember information than those with normal blood pressure levels, a new study finds. Long-term “study of studies” in Latino and non-Latino older adults shows clear hypertension link, but mystery still remains about why dementia risk is higher…
Patients with mild cognitive impairment (MCI) are less likely to receive guideline-concordant treatment for cardiovascular disease and other conditions. Our team conducted a study to explore how a patient’s MCI diagnosis influences physician decision-making for treatment recommendations.
Patients with mild cognitive impairment (MCI) are less likely to receive guideline-concordant treatment for cardiovascular disease and other conditions. Our team conducted a study to explore how a patient’s MCI diagnosis influences physician decision-making for treatment recommendations.
Older patients with pre-existing mild cognitive impairment (MCI) receive less evidence-based care after acute myocardial infarction, however, whether they receive less care after acute ischemic stroke (AIS) is unknown. We compared receipt of guideline-concordant procedures after AIS between older adults with pre-existing MCI and normal cognition.
Patients with mild cognitive impairment (MCI) are less likely to receive guideline-concordant treatment for cardiovascular disease and other conditions. Our team conducted a study to explore how a patient’s MCI diagnosis influences physician decision-making for treatment recommendations.
A new analysis finds higher baseline cognition scores for aging women, but a more rapid drop once cognitive decline begins. JAMA Netw Open. 2021;4(2):e210169. doi:10.1001/jamanetworkopen.2021.0169 Deborah A. Levine, MD, MPH1,2,3; Alden L. Gross, PhD4; Emily M. Briceño, PhD1,3,5; et al Women may start middle age with stronger brain function than men, but as they get older, women’s cognition declines faster. That’s according to…
Please click on the links below for the latest articles in the media related to this study:
Does the risk of cognitive decline among US adults vary by sex? Description: Sex differences in dementia risk are unclear, but some studies have found greater risk for women. The objective of our study was to determine associations between sex and cognitive decline in order to better understand sex differences in dementia risk. In this…
The risk and outcomes of cardiovascular disease (CVD), including stroke, are not distributed randomly throughout society. Instead, CVD risk and outcomes disproportionately affect some groups more than others, including certain racial/ethnic minorities. This special report aims to summarize selected interventions to reduce racial/ethnic disparities in stroke prevention and treatment and reviews the social determinants of health and the determinants of racial/ethnic disparities in care.
We aim to identify risk and resilience factors that impact cognitive health, and to optimize precision in assessment of cognition through consideration of factors (e.g., linguistic, cultural, and educational experiences) that may impact the cognitive assessment process.
We aim to improve precision in harmonization of cognitive data across studies through use of detailed documentation and review procedures to ensure comparability of cognitive data.
The Predictors and Long-Term Trajectory of Poststroke Cognitive Decline study is a completed NIH/NIA-funded study (K23AG040278; principal investigator, Deborah Levine) that aimed to determine the predictors and long-term trajectory of cognitive decline after stroke.
This study will: 1) extend the data collection of Reach Out, our ongoing clinical trial to explore innovative mobile health approaches of measuring cognition and blood pressure among our predominately work-age African American participants; and 2) estimate the prevalence of dementia among hypertensive Emergency Department patients to better understand Emergency Department patients’ needs.
This phase III, open-label, blinded-endpoint assessment, multicenter, randomized, controlled trial will test the effect of treatment of obstructive sleep apnea with CPAP after acute ischemic stroke reduces mortality and cardiovascular events and improves stroke recovery.
This study will determine the relationship of educational attainment, cardiovascular health, and ambient air pollution to the risk for cognitive decline and dementia in a nationally-representative sample of adults in India using new data from the Longitudinal Aging Study in India (LASI).
This study will conduct a follow-up to the 2016 Health and Retirement Study (HRS) Harmonized Cognitive Assessment Protocol (HCAP) sub-study.
This project aims to use door-to-door surveillance in Texas, a non-immigrant, bi-ethnic community, to determine the prevalence and trajectory over time of cognitive impairment and dementia in Mexican Americans and non-Hispanic whites.
The STROKE COG study is an NIH-funded R01 study that aims to advance the understanding of post-stroke dementia and how post-stroke blood pressure, glucose, and lipid levels independently contribute to post-stroke dementia risk.
In this pooled cohort analysis of 19, 378 participants, black individuals, compared with white individuals, had significantly faster declines in global cognition. Differences between black and white individuals in global cognition decline were no longer statistically significant after adjusting for cumulative mean systolic blood pressure.
Researchers target blood pressure in quest to understand, reduce racial disparities in dementia development.
Incident stroke was associated with an acute decline in cognitive function and also accelerated and persistent cognitive decline over 6 years.