Stroke survivors are much more likely than stroke-free adults to develop Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD). The STROKE COG study is an National Institutes of Health (NIH)-funded R01 study that aims to advance the understanding of post-stroke AD/ADRD and how post-stroke blood pressure, glucose, and lipid levels independently contribute to post-stroke AD/ADRD risk. This is a multi-center study in collaboration with researchers from Columbia University, Johns Hopkins University, and the University of Alabama at Birmingham. The study involves pooling and harmonizing data from 4 existing longitudinal cohorts, secondary data analysis, and simulation modeling.
Trajectory of cognitive decline after incident stroke
Levine DA, et al. JAMA. 2015; 314(1):41-51. PMID: 26151265.
Risk factors for post-stroke cognitive Decline: the REGARDS study
Levine DA, et al. Stroke. 2018;49(4):987-994. PMID: 29581343.
Association of blood pressure and cognition after stroke
Levine DA, et al. J Stroke Cerebrovasc Dis. 2020;29(7):104754. PMID: 32370925
Trajectory of Cognitive Decline After Incident Stroke
Jama Network Original Investigation, July 7, 2015
(includes video and audio interviews)