Sex differences in dementia risk are unclear, but some studies have found greater risk for women. The objective of our study was to determine associations between sex and cognitive decline in order to better understand sex differences in dementia risk. In this cohort study using pooled data from 26 088 participants, women, compared with men, had higher baseline performance in global cognition, executive function, and memory. However, women, compared with men, had significantly faster declines in global cognition and executive function, but not memory. The results of this cohort study suggest that women may have greater cognitive reserve but faster cognitive decline than men, which could contribute to sex differences in late-life dementia.
Full study results can be found here:
Deborah A. Levine, MD, MPH; Alden L. Gross, PhD; Emily M. Briceño, PhD; Nicholas Tilton, PhD; Bruno J. Giordani, PhD; Jeremy B. Sussman, MD, MS; Rodney A. Hayward, MD; James F. Burke, MD, MS; Stephanie Hingtgen, MPP; Mitchell S. V. Elkind, MD, MS; Jennifer J. Manly, PhD; Rebecca F. Gottesman, MD, PhD; Darrell J. Gaskin, PhD; Stephen Sidney, MD, MPH; Ralph L. Sacco, MD, MS; Sarah E. Tom, PhD, MPH; Clinton B. Wright, MD, MS; Kristine Yaffe, MD; Andrzej T. Galecki, MD, PhD. Sex Differences in Cognitive Decline Among US Adults.
And also at the online link below: